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WEE1

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gbanco4 edited this page Dec 17, 2024 · 25 revisions

bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

[[TOC]]

Overview

WEE1 is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.

Relevance tier by entity

Entity Tier Description
PMBL 1 high-confidence PMBL/cHL/GZL gene[@reichelFlowSortingExome2015]
DLBCL 1 aSHM target and high-confidence DLBCL gene[@schmitzGeneticsPathogenesisDiffuse2018]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

include:DLBCL_WEE1.md

Mutation pattern and selective pressure estimates

include:dnds_WEE1.md

aSHM regions

chr_name hg19_start hg19_end region regulatory_comment
chr11 9595246 9599502 intron NA

WEE1 Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chr11 9595762 G>C L94F
chr11 9595887 G>A S136N
chr11 9595888 C>G S136R
chr11 9595889 T>G S137A

include:browser_WEE1.md

Expression

include:mermaid_WEE1.md

References

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