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PIM2

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Ryan Morin edited this page Dec 16, 2024 · 23 revisions

bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

[[TOC]]

Overview

PIM2 is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.

Relevance tier by entity

Entity Tier Description
PMBL 1 high-confidence PMBL/cHL/GZL gene[@reichelFlowSortingExome2015]
DLBCL 1 aSHM target and high-confidence DLBCL gene[@reddyGeneticFunctionalDrivers2017; @schmitzGeneticsPathogenesisDiffuse2018; @arthurGenomewideDiscoverySomatic2018]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

include:DLBCL_PIM2.md

Mutation pattern and selective pressure estimates

include:dnds_PIM2.md

aSHM regions

chr_name hg19_start hg19_end region regulatory_comment
chrX 48774756 48776255 TSS active_promoter

include:browser_PIM2.md

Expression

include:mermaid_PIM2.md

References

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