P2RY8
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P2RY8 encodes a G protein–coupled receptor that is expressed on germinal center B cells. Signals through this receptor promote confinement of B cells to the GC niche.[@muppidiLossSignalingGa132014] Downstream signaling through Galpha13 (encoded by GNA13) and S1PR2 is distrupted by mutations of one of these genes in GC lymphomas including the GCB subgroup of DLBCL and BL.[muppidiLossSignalingGa132014]
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
1 | high-confidence BL gene [@muppidiLossSignalingGa132014] |
 |
1 | high-confidence DLBCL gene [@lohrDiscoveryPrioritizationSomatic2012] |
 |
2 | relevance in FL not firmly established |
include:DLBCL_P2RY8.md include:BL_P2RY8.md
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