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rdmorin edited this page Jun 24, 2024 · 32 revisions

title: 'FL genes' bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

Origins of FL genes

Tier 1 FL genes

66 total

Gene Tier First FL evidence Other entities
ACTB 1, aSHM [@wienandGenomicAnalysesFlowsorted2019b; @lohrDiscoveryPrioritizationSomatic2012a]
ARID1A 1 Krysiak et al[@krysiakRecurrentSomaticMutations2017b] [@rossiCodingGenomeSplenic2012c; @zhangGeneticHeterogeneityDiffuse2013; @wienandGenomicAnalysesFlowsorted2019b; @loveGeneticLandscapeMutations2012]
ATP6AP1 1 Okosun et al[@okosunRecurrentMTORC1activatingRRAGC2016a]
ATP6V1B2 1 Okosun et al[@okosunRecurrentMTORC1activatingRRAGC2016a]
B2M 1 Morin et al[@morinFrequentMutationHistonemodifying2011] [@reichelFlowSortingExome2015a; @pararajalingamCodingNoncodingDrivers2020]
BCL2 1, aSHM Morin et al[@morinFrequentMutationHistonemodifying2011] [@sarkozyMutationalLandscapeGray2021a; @tanakaFrequentIncidenceSomatic1992; @burkhardtClinicalRelevanceMolecular2022b]
BCL6 1, aSHM [@loveGeneticLandscapeMutations2012; @morinFrequentMutationHistonemodifying2011]
BCL7A 1, aSHM Krysiak et al[@krysiakRecurrentSomaticMutations2017b] [@reichelFlowSortingExome2015a; @grandeGenomewideDiscoverySomatic2019; @arthurGenomewideDiscoverySomatic2018]
BIRC6 1 [@sarkozyMutationalLandscapeGray2021a; @reddyGeneticFunctionalDrivers2017]
BTG1 1, aSHM [@burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011; @sarkozyMutationalLandscapeGray2021a]
BTG2 1, aSHM Morin et al[@morinFrequentMutationHistonemodifying2011] [@loveGeneticLandscapeMutations2012]
BTK 1 Krysiak et al[@krysiakRecurrentSomaticMutations2017b] [@albuquerqueEnhancingKnowledgeDiscovery2017a]
CARD11 1 Morin et al[@morinFrequentMutationHistonemodifying2011] [@lenzOncogenicCARD11Mutations2008; @yanBCRTLRSignaling2012a; @wuGeneticHeterogeneityPrimary2016; @paneaWholeGenomeLandscape2019]
CCND3 1 Morin et al[@morinFrequentMutationHistonemodifying2011] [@richterRecurrentMutationID32012a; @deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017]
CD83 1, aSHM Russler et al[@russler-germainMutationsAssociatedProgression2023b] [@morinMutationalStructuralAnalysis2013; @dunsCharacterizationDLBCLPMBL2021b; @paneaWholeGenomeLandscape2019]
CREBBP 1 Pasqualucci et al[@pasqualucciInactivatingMutationsAcetyltransferase2011a] [@dunsCharacterizationDLBCLPMBL2021b; @loveGeneticLandscapeMutations2012; @parryWholeExomeSequencing2013]
CTSS 1 Bararia et al[@barariaCathepsinAlterationsInduce2020c]
DTX1 1, aSHM [@schmitzGeneticsPathogenesisDiffuse2018a; @rossiCodingGenomeSplenic2012c; @gomezUltraDeepSequencingReveals2023; @loveGeneticLandscapeMutations2012]
EBF1 1, aSHM [@reichelFlowSortingExome2015a; @thomasGeneticSubgroupsInform2023; @bohleRoleEarlyBcell2013]
EEF1A1 1 Hubschmann et al[@hubschmannMutationalMechanismsShaping2021b] [@reichelFlowSortingExome2015a]
EP300 1 Pasqualucci et al[@pasqualucciInactivatingMutationsAcetyltransferase2011a] [@paneaWholeGenomeLandscape2019; @rossiCodingGenomeSplenic2012c]
EZH2 1 Morin et al[@morinSomaticMutationsAltering2010a] [@mottokIntegrativeGenomicAnalysis2019b; @loveGeneticLandscapeMutations2012]
FAS 1 [@schollMutationsRegionFAS2007; @spinaGeneticsNodalMarginal2016b]
FOXO1 1 Morin et al[@morinFrequentMutationHistonemodifying2011] [@schmitzBurkittLymphomaPathogenesis2012; @dunsCharacterizationDLBCLPMBL2021b]
GNA13 1 Morin et al[@morinFrequentMutationHistonemodifying2011] [@reichelFlowSortingExome2015a; @loveGeneticLandscapeMutations2012]
GNAI2 1 [@morinMutationalStructuralAnalysis2013; @grandeGenomewideDiscoverySomatic2019]
HIST1H1B 1, aSHM Krysiak et al[@krysiakRecurrentSomaticMutations2017b] [@chapuyMolecularSubtypesDiffuse2018b; @sarkozyMutationalLandscapeGray2021a]
HIST1H1C 1, aSHM Morin et al[@morinFrequentMutationHistonemodifying2011] [@paneaWholeGenomeLandscape2019]
HIST1H1D 1, aSHM Krysiak et al[@krysiakRecurrentSomaticMutations2017b] [@morinMutationalStructuralAnalysis2013; @jalladesExomeSequencingIdentifies2017]
HIST1H1E 1, aSHM Krysiak et al[@krysiakRecurrentSomaticMutations2017b] [@grandeGenomewideDiscoverySomatic2019; @reichelFlowSortingExome2015a; @lohrDiscoveryPrioritizationSomatic2012a]
HIST1H2AC 1, aSHM Krysiak et al[@krysiakRecurrentSomaticMutations2017b] [@morinMutationalStructuralAnalysis2013]
HIST1H2AG 1, aSHM Krysiak et al[@krysiakRecurrentSomaticMutations2017b] [@paneaWholeGenomeLandscape2019; @rossiCodingGenomeSplenic2012c; @morinMutationalStructuralAnalysis2013]
HIST1H2AM 1, aSHM Krysiak et al[@krysiakRecurrentSomaticMutations2017b] [@paneaWholeGenomeLandscape2019]
HIST1H2BC 1, aSHM Krysiak et al[@krysiakRecurrentSomaticMutations2017b] [@mottokIntegrativeGenomicAnalysis2019b; @lohrDiscoveryPrioritizationSomatic2012a]
HIST1H2BD 1, aSHM Krysiak et al[@krysiakRecurrentSomaticMutations2017b]
HIST1H2BG 1, aSHM Krysiak et al[@krysiakRecurrentSomaticMutations2017b]
HIST1H3B 1, aSHM [@lohrDiscoveryPrioritizationSomatic2012a; @reichelFlowSortingExome2015a]
HIST1H3G 1, aSHM Krysiak et al[@krysiakRecurrentSomaticMutations2017b]
HVCN1 1 Krysiak et al[@krysiakRecurrentSomaticMutations2017b]
IRF4 1, aSHM [@morinFrequentMutationHistonemodifying2011; @mottokIntegrativeGenomicAnalysis2019b]
IRF8 1, aSHM Morin et al[@morinFrequentMutationHistonemodifying2011] [@mottokIntegrativeGenomicAnalysis2019b; @paneaWholeGenomeLandscape2019]
ITPKB 1, aSHM [@schmitzGeneticsPathogenesisDiffuse2018a; @reichelFlowSortingExome2015a]
KLF2 1, aSHM [@pasqualucciAnalysisCodingGenome2011; @jalladesExomeSequencingIdentifies2017; @deschGenotypingCirculatingTumor2020]
KLHL6 1, aSHM Morin et al[@morinFrequentMutationHistonemodifying2011] [@paneaWholeGenomeLandscape2019; @ganapathiGeneticLandscapeDural2016]
KMT2D 1 Morin et al[@morinFrequentMutationHistonemodifying2011] [@grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012c; @deschGenotypingCirculatingTumor2020; @beaLandscapeSomaticMutations2013]
LTB 1, aSHM [@chapuyMolecularSubtypesDiffuse2018b; @paneaWholeGenomeLandscape2019; @deschGenotypingCirculatingTumor2020]
MAP2K1 1 Louissaint et al[@louissaintPediatrictypeNodalFollicular2016a] [@shinBRAFV600EMAP2K12015]
MEF2B 1, aSHM Morin et al[@morinFrequentMutationHistonemodifying2011] [@beaLandscapeSomaticMutations2013]
MEF2C 1, aSHM [@arthurGenomewideDiscoverySomatic2018]
PCLO 1 [@lohrDiscoveryPrioritizationSomatic2012a]
PIM1 1, aSHM [@dunsCharacterizationDLBCLPMBL2021b; @burkhardtClinicalRelevanceMolecular2022b; @pasqualucciHypermutationMultipleProtooncogenes2001a]
POU2AF1 1 Krysiak et al[@krysiakRecurrentSomaticMutations2017b]
POU2F2 1 Krysiak et al[@krysiakRecurrentSomaticMutations2017b] [@lohrDiscoveryPrioritizationSomatic2012a]
PTPRD 1 [@spinaGeneticsNodalMarginal2016b]
RRAGC 1 [@okosunRecurrentMTORC1activatingRRAGC2016a]
S1PR2 1, aSHM [@morinFrequentMutationHistonemodifying2011; @muppidiLossSignalingGa132014b]
SGK1 1, aSHM Morin et al[@morinFrequentMutationHistonemodifying2011] [@dunsCharacterizationDLBCLPMBL2021b]
SMARCA4 1 Krysiak et al[@krysiakRecurrentSomaticMutations2017b] [@nadeuGenomicEpigenomicInsights2020b; @lohrDiscoveryPrioritizationSomatic2012a; @richterRecurrentMutationID32012a]
SOCS1 1, aSHM [@morinFrequentMutationHistonemodifying2011; @wenigerMutationsTumorSuppressor2006a]
STAT6 1 Yildiz et al[@yildizActivatingSTAT6Mutations2015c] [@ritzRecurrentMutationsSTAT62009a]
TBL1XR1 1 [@rossiCodingGenomeSplenic2012c; @lohrDiscoveryPrioritizationSomatic2012a]
TMSB4X 1, aSHM [@albuquerqueEnhancingKnowledgeDiscovery2017a]
TNFAIP3 1 [@compagnoMutationsMultipleGenes2009a; @rossiAlterationBIRC3Multiple2011a; @schmitzTNFAIP3A20Tumor2009a]
TNFRSF14 1 Cheung et al[@cheungAcquiredTNFRSF14Mutations2010a] [@morinFrequentMutationHistonemodifying2011; @spinaGeneticsNodalMarginal2016b]
TP53 1 Morin et al[@morinFrequentMutationHistonemodifying2011] [@wildaInactivationARFMDM2p53Pathway2004; @beaLandscapeSomaticMutations2013; @tiacciPervasiveMutationsJAKSTAT2018b; @lohrDiscoveryPrioritizationSomatic2012a; @rossiCodingGenomeSplenic2012c]
VMA21 1 Hubschmann et al[@hubschmannMutationalMechanismsShaping2021b]

Tier 2 FL genes

50 total

Gene Tier First FL evidence Other entities
ABL2 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b]
ACTG1 2, aSHM Hubschmann et al[@hubschmannMutationalMechanismsShaping2021b] [@spinaGeneticsNodalMarginal2016b; @deschGenotypingCirculatingTumor2020]
ATP6V1A 2 Hubschmann et al[@hubschmannMutationalMechanismsShaping2021b]
BCL10 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b] [@morinFrequentMutationHistonemodifying2011; @spinaGeneticsNodalMarginal2016b]
CD70 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b] [@morinFrequentMutationHistonemodifying2011]
CD79B 2 [@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]
CDC42BPB 2 Hubschmann et al[@hubschmannMutationalMechanismsShaping2021b] [@spinaGeneticsNodalMarginal2016b]
CILP 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b]
CPNE8 2 Hubschmann et al[@hubschmannMutationalMechanismsShaping2021b]
CXCR4 2, aSHM Krysiak et al[@krysiakRecurrentSomaticMutations2017b] [@khodabakhshiRecurrentTargetsAberrant2012; @paneaWholeGenomeLandscape2019]
CYP2A6 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b]
DDX3X 2 [@schmitzBurkittLymphomaPathogenesis2012; @mottokIntegrativeGenomicAnalysis2019b; @schmitzGeneticsPathogenesisDiffuse2018a]
DHX15 2 Hubschmann et al[@hubschmannMutationalMechanismsShaping2021b]
DUSP2 2, aSHM [@dunsCharacterizationDLBCLPMBL2021b; @lohrDiscoveryPrioritizationSomatic2012a]
EGR1 2 Krysiak et al[@krysiakRecurrentSomaticMutations2017b] [@reichelFlowSortingExome2015a; @rossiCodingGenomeSplenic2012c]
FZR1 2 Hubschmann et al[@hubschmannMutationalMechanismsShaping2021b]
GBP7 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b]
GRM6 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b]
HIST1H2BM 2, aSHM Krysiak et al[@krysiakRecurrentSomaticMutations2017b]
HIST1H3I 2, aSHM Krysiak et al[@krysiakRecurrentSomaticMutations2017b] [@paneaWholeGenomeLandscape2019]
HLA-B 2 [@lohrDiscoveryPrioritizationSomatic2012a; @wienandGenomicAnalysesFlowsorted2019b]
IGLL5 2, aSHM Russler et al[@russler-germainMutationsAssociatedProgression2023b] [@deschGenotypingCirculatingTumor2020; @paneaWholeGenomeLandscape2019]
JUP 2 Hubschmann et al[@hubschmannMutationalMechanismsShaping2021b]
KIR3DL1 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b]
LAPTM5 2 Hubschmann et al[@hubschmannMutationalMechanismsShaping2021b]
MAGEC1 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b]
MAP7D1 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b]
MGEA5 2 Hubschmann et al[@hubschmannMutationalMechanismsShaping2021b]
MKI67 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b] [@schmitzBurkittLymphomaPathogenesis2012]
MYC 2, aSHM [@johnstonCmycHypermutationBurkitt1992; @jalladesExomeSequencingIdentifies2017; @dunsCharacterizationDLBCLPMBL2021b; @pasqualucciHypermutationMultipleProtooncogenes2001a]
MYCBP2 2 Hubschmann et al[@hubschmannMutationalMechanismsShaping2021b]
MYD88 2 [@yanBCRTLRSignaling2012a; @ngoOncogenicallyActiveMYD882011a]
NFKBIA 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b] [@lakeMutationsNFKBIAEncoding2009; @wienandGenomicAnalysesFlowsorted2019b]
OR8H2 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b]
P2RY8 2 [@muppidiLossSignalingGa132014b; @lohrDiscoveryPrioritizationSomatic2012a]
PDS5B 2 Hubschmann et al[@hubschmannMutationalMechanismsShaping2021b] [@morinMutationalStructuralAnalysis2013]
PPP4C 2 Hubschmann et al[@hubschmannMutationalMechanismsShaping2021b]
PRKDC 2 Hubschmann et al[@hubschmannMutationalMechanismsShaping2021b] [@schmitzGeneticsPathogenesisDiffuse2018a]
PZP 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b]
RBM6 2 Hubschmann et al[@hubschmannMutationalMechanismsShaping2021b]
SHROOM3 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b]
SRRM2 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b] [@morinMutationalStructuralAnalysis2013]
STAB2 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b]
TMEM30A 2 Morin et al[@morinFrequentMutationHistonemodifying2011]
TPP1 2 Hubschmann et al[@hubschmannMutationalMechanismsShaping2021b]
XIRP2 2 Russler et al[@russler-germainMutationsAssociatedProgression2023b]
ZC3H12A 2 [@arthurGenomewideDiscoverySomatic2018]
ZNF608 2 Krysiak et al[@krysiakRecurrentSomaticMutations2017b] [@zhangGeneticHeterogeneityDiffuse2013]

References

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