FL_genes

---

title: 'FL genes' bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

Origins of FL genes

Tier 1 FL genes

66 total

Gene	Tier	First FL evidence	Other entities
ACTB	1, aSHM		[@lohrDiscoveryPrioritizationSomatic2012a; @wienandGenomicAnalysesFlowsorted2019b]
ARID1A	1	[@krysiakRecurrentSomaticMutations2017b]	[@loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @zhangGeneticHeterogeneityDiffuse2013; @wienandGenomicAnalysesFlowsorted2019b]
ATP6AP1	1	[@okosunRecurrentMTORC1activatingRRAGC2016a]
ATP6V1B2	1	[@okosunRecurrentMTORC1activatingRRAGC2016a]
B2M	1	[@morinFrequentMutationHistonemodifying2011]	[@pararajalingamCodingNoncodingDrivers2020; @reichelFlowSortingExome2015a]
BCL2	1, aSHM	[@morinFrequentMutationHistonemodifying2011]	[@burkhardtClinicalRelevanceMolecular2022b; @sarkozyMutationalLandscapeGray2021a; @tanakaFrequentIncidenceSomatic1992]
BCL6	1, aSHM		[@morinFrequentMutationHistonemodifying2011; @loveGeneticLandscapeMutations2012]
BCL7A	1, aSHM	[@krysiakRecurrentSomaticMutations2017b]	[@arthurGenomewideDiscoverySomatic2018; @reichelFlowSortingExome2015a; @grandeGenomewideDiscoverySomatic2019]
BIRC6	1		[@reddyGeneticFunctionalDrivers2017; @sarkozyMutationalLandscapeGray2021a]
BTG1	1, aSHM		[@morinFrequentMutationHistonemodifying2011; @burkhardtClinicalRelevanceMolecular2022b; @sarkozyMutationalLandscapeGray2021a]
BTG2	1, aSHM	[@morinFrequentMutationHistonemodifying2011]	[@loveGeneticLandscapeMutations2012]
BTK	1	[@krysiakRecurrentSomaticMutations2017b]	[@albuquerqueEnhancingKnowledgeDiscovery2017a]
CARD11	1	[@morinFrequentMutationHistonemodifying2011]	[@lenzOncogenicCARD11Mutations2008; @wuGeneticHeterogeneityPrimary2016; @paneaWholeGenomeLandscape2019; @yanBCRTLRSignaling2012a]
CCND3	1	[@morinFrequentMutationHistonemodifying2011]	[@richterRecurrentMutationID32012a; @jalladesExomeSequencingIdentifies2017; @deschGenotypingCirculatingTumor2020]
CD83	1, aSHM	[@russler-germainMutationsAssociatedProgression2023b]	[@paneaWholeGenomeLandscape2019; @dunsCharacterizationDLBCLPMBL2021b; @morinMutationalStructuralAnalysis2013]
CREBBP	1	[@pasqualucciInactivatingMutationsAcetyltransferase2011a]	[@parryWholeExomeSequencing2013; @dunsCharacterizationDLBCLPMBL2021b; @loveGeneticLandscapeMutations2012]
CTSS	1	[@barariaCathepsinAlterationsInduce2020c]
DTX1	1, aSHM		[@schmitzGeneticsPathogenesisDiffuse2018a; @rossiCodingGenomeSplenic2012c; @gomezUltraDeepSequencingReveals2023; @paneaWholeGenomeLandscape2019]
EBF1	1, aSHM		[@thomasGeneticSubgroupsInform2023; @reichelFlowSortingExome2015a; @bohleRoleEarlyBcell2013]
EEF1A1	1	[@hubschmannMutationalMechanismsShaping2021b]	[@reichelFlowSortingExome2015a]
EP300	1	[@pasqualucciInactivatingMutationsAcetyltransferase2011a]	[@rossiCodingGenomeSplenic2012c; @paneaWholeGenomeLandscape2019]
EZH2	1	[@morinSomaticMutationsAltering2010a]	[@mottokIntegrativeGenomicAnalysis2019b; @loveGeneticLandscapeMutations2012]
FAS	1		[@spinaGeneticsNodalMarginal2016b; @schollMutationsRegionFAS2007]
FOXO1	1	[@morinFrequentMutationHistonemodifying2011]	[@schmitzBurkittLymphomaPathogenesis2012; @dunsCharacterizationDLBCLPMBL2021b]
GNA13	1	[@morinFrequentMutationHistonemodifying2011]	[@reichelFlowSortingExome2015a; @loveGeneticLandscapeMutations2012]
GNAI2	1		[@grandeGenomewideDiscoverySomatic2019; @morinMutationalStructuralAnalysis2013]
HIST1H1B	1, aSHM	[@krysiakRecurrentSomaticMutations2017b]	[@chapuyMolecularSubtypesDiffuse2018b; @sarkozyMutationalLandscapeGray2021a]
HIST1H1C	1, aSHM	[@morinFrequentMutationHistonemodifying2011]	[@paneaWholeGenomeLandscape2019]
HIST1H1D	1, aSHM	[@krysiakRecurrentSomaticMutations2017b]	[@morinMutationalStructuralAnalysis2013; @jalladesExomeSequencingIdentifies2017]
HIST1H1E	1, aSHM	[@krysiakRecurrentSomaticMutations2017b]	[@morinMutationalStructuralAnalysis2013; @reichelFlowSortingExome2015a; @grandeGenomewideDiscoverySomatic2019]
HIST1H2AC	1, aSHM	[@krysiakRecurrentSomaticMutations2017b]	[@morinMutationalStructuralAnalysis2013]
HIST1H2AG	1, aSHM	[@krysiakRecurrentSomaticMutations2017b]	[@morinMutationalStructuralAnalysis2013; @rossiCodingGenomeSplenic2012c; @paneaWholeGenomeLandscape2019]
HIST1H2AM	1, aSHM	[@krysiakRecurrentSomaticMutations2017b]	[@paneaWholeGenomeLandscape2019]
HIST1H2BC	1, aSHM	[@krysiakRecurrentSomaticMutations2017b]	[@mottokIntegrativeGenomicAnalysis2019b; @reddyGeneticFunctionalDrivers2017]
HIST1H2BD	1, aSHM	[@krysiakRecurrentSomaticMutations2017b]
HIST1H2BG	1, aSHM	[@krysiakRecurrentSomaticMutations2017b]
HIST1H3B	1, aSHM		[@zhangGeneticHeterogeneityDiffuse2013; @reichelFlowSortingExome2015a]
HIST1H3G	1, aSHM	[@krysiakRecurrentSomaticMutations2017b]
HVCN1	1	[@krysiakRecurrentSomaticMutations2017b]
IRF4	1, aSHM		[@mottokIntegrativeGenomicAnalysis2019b; @morinFrequentMutationHistonemodifying2011]
IRF8	1, aSHM	[@morinFrequentMutationHistonemodifying2011]	[@mottokIntegrativeGenomicAnalysis2019b; @paneaWholeGenomeLandscape2019]
ITPKB	1, aSHM		[@reichelFlowSortingExome2015a; @schmitzGeneticsPathogenesisDiffuse2018a]
KLF2	1, aSHM		[@jalladesExomeSequencingIdentifies2017; @deschGenotypingCirculatingTumor2020; @pasqualucciAnalysisCodingGenome2011]
KLHL6	1, aSHM	[@morinFrequentMutationHistonemodifying2011]	[@paneaWholeGenomeLandscape2019; @ganapathiGeneticLandscapeDural2016]
KMT2D	1	[@morinFrequentMutationHistonemodifying2011]	[@grandeGenomewideDiscoverySomatic2019; @beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020; @rossiCodingGenomeSplenic2012c]
LTB	1, aSHM		[@chapuyMolecularSubtypesDiffuse2018b; @deschGenotypingCirculatingTumor2020; @paneaWholeGenomeLandscape2019]
MAP2K1	1	[@louissaintPediatrictypeNodalFollicular2016a]	[@shinBRAFV600EMAP2K12015]
MEF2B	1, aSHM	[@morinFrequentMutationHistonemodifying2011]	[@beaLandscapeSomaticMutations2013]
MEF2C	1, aSHM		[@arthurGenomewideDiscoverySomatic2018]
PCLO	1		[@lohrDiscoveryPrioritizationSomatic2012a]
PIM1	1, aSHM		[@dunsCharacterizationDLBCLPMBL2021b; @burkhardtClinicalRelevanceMolecular2022b; @pasqualucciHypermutationMultipleProtooncogenes2001a]
POU2AF1	1	[@krysiakRecurrentSomaticMutations2017b]
POU2F2	1	[@krysiakRecurrentSomaticMutations2017b]	[@zhangGeneticHeterogeneityDiffuse2013]
PTPRD	1		[@spinaGeneticsNodalMarginal2016b]
RRAGC	1		[@okosunRecurrentMTORC1activatingRRAGC2016a]
S1PR2	1, aSHM		[@morinFrequentMutationHistonemodifying2011; @muppidiLossSignalingGa132014b]
SGK1	1, aSHM	[@morinFrequentMutationHistonemodifying2011]	[@dunsCharacterizationDLBCLPMBL2021b]
SMARCA4	1	[@krysiakRecurrentSomaticMutations2017b]	[@richterRecurrentMutationID32012a; @zhangGeneticHeterogeneityDiffuse2013; @nadeuGenomicEpigenomicInsights2020b]
SOCS1	1, aSHM		[@wenigerMutationsTumorSuppressor2006a; @morinFrequentMutationHistonemodifying2011]
STAT6	1	[@yildizActivatingSTAT6Mutations2015c]	[@ritzRecurrentMutationsSTAT62009a]
TBL1XR1	1		[@rossiCodingGenomeSplenic2012c; @mareschalWholeExomeSequencing2016]
TMSB4X	1, aSHM		[@albuquerqueEnhancingKnowledgeDiscovery2017a]
TNFAIP3	1		[@rossiAlterationBIRC3Multiple2011a; @compagnoMutationsMultipleGenes2009a; @schmitzTNFAIP3A20Tumor2009a]
TNFRSF14	1	[@cheungAcquiredTNFRSF14Mutations2010a]	[@spinaGeneticsNodalMarginal2016b]
TP53	1	[@morinFrequentMutationHistonemodifying2011]	[@wildaInactivationARFMDM2p53Pathway2004; @rossiCodingGenomeSplenic2012c; @beaLandscapeSomaticMutations2013; @tiacciPervasiveMutationsJAKSTAT2018b]
VMA21	1	[@hubschmannMutationalMechanismsShaping2021b]

Tier 2 FL genes

50 total

Gene	Tier	First FL evidence	Other entities
ABL2	2	[@russler-germainMutationsAssociatedProgression2023b]
ACTG1	2, aSHM	[@hubschmannMutationalMechanismsShaping2021b]	[@spinaGeneticsNodalMarginal2016b; @deschGenotypingCirculatingTumor2020]
ATP6V1A	2	[@hubschmannMutationalMechanismsShaping2021b]
BCL10	2	[@russler-germainMutationsAssociatedProgression2023b]	[@morinFrequentMutationHistonemodifying2011; @spinaGeneticsNodalMarginal2016b]
CCDC42BPB	2	[@hubschmannMutationalMechanismsShaping2021b]
CD70	2	[@russler-germainMutationsAssociatedProgression2023b]	[@morinFrequentMutationHistonemodifying2011]
CD79B	2		[@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]
CILP	2	[@russler-germainMutationsAssociatedProgression2023b]
CPNE8	2	[@hubschmannMutationalMechanismsShaping2021b]
CXCR4	2, aSHM	[@krysiakRecurrentSomaticMutations2017b]	[@paneaWholeGenomeLandscape2019; @khodabakhshiRecurrentTargetsAberrant2012]
CYP2A6	2	[@russler-germainMutationsAssociatedProgression2023b]
DDX3X	2		[@schmitzBurkittLymphomaPathogenesis2012; @schmitzGeneticsPathogenesisDiffuse2018a; @mottokIntegrativeGenomicAnalysis2019b]
DHX15	2	[@hubschmannMutationalMechanismsShaping2021b]
DUSP2	2, aSHM		[@morinMutationalStructuralAnalysis2013; @dunsCharacterizationDLBCLPMBL2021b]
EGR1	2	[@krysiakRecurrentSomaticMutations2017b]	[@reichelFlowSortingExome2015a; @rossiCodingGenomeSplenic2012c]
FZR1	2	[@hubschmannMutationalMechanismsShaping2021b]
GBP7	2	[@russler-germainMutationsAssociatedProgression2023b]
GRM6	2	[@russler-germainMutationsAssociatedProgression2023b]
HIST1H2BM	2, aSHM	[@krysiakRecurrentSomaticMutations2017b]
HIST1H3I	2, aSHM	[@krysiakRecurrentSomaticMutations2017b]	[@paneaWholeGenomeLandscape2019]
HLA-B	2		[@wienandGenomicAnalysesFlowsorted2019b]
HNRNPD	2
IGLL5	2, aSHM	[@russler-germainMutationsAssociatedProgression2023b]	[@deschGenotypingCirculatingTumor2020; @paneaWholeGenomeLandscape2019]
JUP	2	[@hubschmannMutationalMechanismsShaping2021b]
KIR3DL1	2	[@russler-germainMutationsAssociatedProgression2023b]
LAPTM5	2	[@hubschmannMutationalMechanismsShaping2021b]
MAGEC1	2	[@russler-germainMutationsAssociatedProgression2023b]
MAP7D1	2	[@russler-germainMutationsAssociatedProgression2023b]
MGEA5	2	[@hubschmannMutationalMechanismsShaping2021b]
MKI67	2	[@russler-germainMutationsAssociatedProgression2023b]	[@schmitzBurkittLymphomaPathogenesis2012]
MYC	2, aSHM		[@johnstonCmycHypermutationBurkitt1992; @jalladesExomeSequencingIdentifies2017; @dunsCharacterizationDLBCLPMBL2021b; @pasqualucciHypermutationMultipleProtooncogenes2001a]
MYCBP2	2	[@hubschmannMutationalMechanismsShaping2021b]
MYD88	2		[@ngoOncogenicallyActiveMYD882011a; @yanBCRTLRSignaling2012a]
NFKBIA	2	[@russler-germainMutationsAssociatedProgression2023b]	[@wienandGenomicAnalysesFlowsorted2019b; @lakeMutationsNFKBIAEncoding2009]
OR8H2	2	[@russler-germainMutationsAssociatedProgression2023b]
P2RY8	2		[@muppidiLossSignalingGa132014b; @lohrDiscoveryPrioritizationSomatic2012a]
PDS5B	2	[@hubschmannMutationalMechanismsShaping2021b]	[@morinMutationalStructuralAnalysis2013]
PPP4C	2	[@hubschmannMutationalMechanismsShaping2021b]
PRKDC	2	[@hubschmannMutationalMechanismsShaping2021b]	[@schmitzGeneticsPathogenesisDiffuse2018a]
PZP	2	[@russler-germainMutationsAssociatedProgression2023b]
RBM6	2	[@hubschmannMutationalMechanismsShaping2021b]
SESN1	2	[@oricchioGeneticEpigeneticInactivation2017b]
SHROOM3	2	[@russler-germainMutationsAssociatedProgression2023b]
SRRM2	2	[@russler-germainMutationsAssociatedProgression2023b]	[@morinMutationalStructuralAnalysis2013]
STAB2	2	[@russler-germainMutationsAssociatedProgression2023b]
TMEM30A	2	[@morinFrequentMutationHistonemodifying2011]
TPP1	2	[@hubschmannMutationalMechanismsShaping2021b]
XIRP2	2	[@russler-germainMutationsAssociatedProgression2023b]
ZC3H12A	2		[@arthurGenomewideDiscoverySomatic2018]
ZNF608	2	[@krysiakRecurrentSomaticMutations2017b]	[@zhangGeneticHeterogeneityDiffuse2013]

References