FL_genes

---

title: 'FL genes' bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

Origins of FL genes

Tier 1, high-confidence FL genes

54 total

Gene	Summary	First FL study	Other entities	QC result
ACTB	Tier 1 GE[@drevalGeneticSubdivisionsFollicular2023], aSHM	Dreval et al	[@lohrDiscoveryPrioritizationSomatic2012a; @wienandGenomicAnalysesFlowsorted2019b]
ARID1A	Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], FE[@barisicARID1AOrchestratesSWI2024], aSHM	Krysiak et al	[@loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @wienandGenomicAnalysesFlowsorted2019b; @zhangGeneticHeterogeneityDiffuse2013]
ATP6AP1	Tier 1 GE[@okosunRecurrentMTORC1activatingRRAGC2016a]	Okosun et al
ATP6V1B2	Tier 1 GE[@okosunRecurrentMTORC1activatingRRAGC2016a]	Okosun et al
B2M	Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@challa-malladiCombinedGeneticInactivationa], aSHM	Morin et al	[@pararajalingamCodingNoncodingDrivers2020; @reichelFlowSortingExome2015a]
BCL10	Tier 1 GE[@russler-germainMutationsAssociatedProgression2023b], FE[@xiaBCL10MutationsDefine2022], aSHM	Russler-germain et al	[@morinFrequentMutationHistonemodifying2011; @spinaGeneticsNodalMarginal2016b]
BCL2	Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@balSuperenhancerHypermutationAlters2022], aSHM	Morin et al	[@burkhardtClinicalRelevanceMolecular2022b; @sarkozyMutationalLandscapeGray2021a; @tanakaFrequentIncidenceSomatic1992]
BCL6	Tier 1 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@balSuperenhancerHypermutationAlters2022], aSHM	Dreval et al	[@loveGeneticLandscapeMutations2012; @morinFrequentMutationHistonemodifying2011]
BCL7A	Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], FE[@balinas-gaviraFrequentMutationsAminoterminal2020b], aSHM	Krysiak et al	[@grandeGenomewideDiscoverySomatic2019; @morinFrequentMutationHistonemodifying2011; @reichelFlowSortingExome2015a]
BTK	Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], aSHM	Krysiak et al	[@albuquerqueEnhancingKnowledgeDiscovery2017a]
CARD11	Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@lenzOncogenicCARD11Mutations2008], CE[@zhaoExpressionPrognosticValue2016], aSHM	Morin et al	[@lenzOncogenicCARD11Mutations2008; @wuGeneticHeterogeneityPrimary2016; @yanBCRTLRSignaling2012a]
CCND3	Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@schmitzBurkittLymphomaPathogenesis2012], aSHM	Morin et al	[@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017; @richterRecurrentMutationID32012a]
CD83	Tier 1 GE[@russler-germainMutationsAssociatedProgression2023b], aSHM	Russler-germain et al	[@dunsCharacterizationDLBCLPMBL2021b; @morinMutationalStructuralAnalysis2013; @paneaWholeGenomeLandscape2019]
CREBBP	Tier 1 GE[@pasqualucciInactivatingMutationsAcetyltransferase2011a], FE[@pasqualucciInactivatingMutationsAcetyltransferase2011a], aSHM	Pasqualucci et al	[@dunsCharacterizationDLBCLPMBL2021b; @loveGeneticLandscapeMutations2012; @parryWholeExomeSequencing2013]
CTSS	Tier 1 GE[@barariaCathepsinAlterationsInduce2020c]	Bararia et al
EBF1	Tier 1 GE, aSHM		[@bohleRoleEarlyBcell2013; @reichelFlowSortingExome2015a; @thomasGeneticSubgroupsInform2023]
EEF1A1	Tier 1 GE[@hubschmannMutationalMechanismsShaping2021b], CE[@gongExpressionClinicalValue2021], aSHM	Hubschmann et al	[@reichelFlowSortingExome2015a]
EP300	Tier 1 GE[@pasqualucciInactivatingMutationsAcetyltransferase2011a], FE[@pasqualucciInactivatingMutationsAcetyltransferase2011a], aSHM	Pasqualucci et al	[@rossiCodingGenomeSplenic2012c]
EZH2	Tier 1 GE[@morinSomaticMutationsAltering2010a], FE[@yapSomaticMutationsEZH22011b], aSHM	Morin et al	[@loveGeneticLandscapeMutations2012; @mottokIntegrativeGenomicAnalysis2019b]
FAS	Tier 1 GE, FE[@seebergerLossFasCD952001], aSHM		[@schollMutationsRegionFAS2007; @spinaGeneticsNodalMarginal2016b]
FOXO1	Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@trinhAnalysisFOXO1Mutations], CE[@trinhAnalysisFOXO1Mutations], aSHM	Morin et al	[@dunsCharacterizationDLBCLPMBL2021b; @schmitzBurkittLymphomaPathogenesis2012]
GNA13	Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@muppidiLossSignalingGa132014b], aSHM	Morin et al	[@loveGeneticLandscapeMutations2012; @reichelFlowSortingExome2015a]
GNAI2	Tier 1 GE, aSHM		[@grandeGenomewideDiscoverySomatic2019; @morinMutationalStructuralAnalysis2013]
HIST1H1B	Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], aSHM	Krysiak et al	[@chapuyMolecularSubtypesDiffuse2018b; @sarkozyMutationalLandscapeGray2021a]
HIST1H1C	Tier 1 GE[@morinFrequentMutationHistonemodifying2011], aSHM	Morin et al	[@paneaWholeGenomeLandscape2019]
HIST1H1D	Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], aSHM	Krysiak et al	[@jalladesExomeSequencingIdentifies2017; @morinMutationalStructuralAnalysis2013]
HIST1H1E	Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], aSHM	Krysiak et al	[@grandeGenomewideDiscoverySomatic2019; @lohrDiscoveryPrioritizationSomatic2012a; @reichelFlowSortingExome2015a]
HIST1H2AC	Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], aSHM	Krysiak et al	[@morinMutationalStructuralAnalysis2013]
HIST1H2AG	Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], aSHM	Krysiak et al	[@morinMutationalStructuralAnalysis2013; @paneaWholeGenomeLandscape2019; @rossiCodingGenomeSplenic2012c]
HIST1H2AM	Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], aSHM	Krysiak et al	[@chapuyMolecularSubtypesDiffuse2018b; @paneaWholeGenomeLandscape2019]
HIST1H2BC	Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], aSHM	Krysiak et al	[@lohrDiscoveryPrioritizationSomatic2012a; @mottokIntegrativeGenomicAnalysis2019b]
HIST1H2BG	Tier 1 GE[@krysiakRecurrentSomaticMutations2017b]	Krysiak et al
HVCN1	Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], aSHM	Krysiak et al	[@chapuyMolecularSubtypesDiffuse2018b]
IRF4	Tier 1 GE[@drevalGeneticSubdivisionsFollicular2023], aSHM	Dreval et al	[@morinFrequentMutationHistonemodifying2011; @mottokIntegrativeGenomicAnalysis2019b]
IRF8	Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@qiuIRF8mutantCellLymphoma2024], aSHM	Morin et al	[@mottokIntegrativeGenomicAnalysis2019b; @paneaWholeGenomeLandscape2019]
KLHL6	Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@merirantaDisruptionKLHL6Fuels2024], aSHM	Morin et al	[@ganapathiGeneticLandscapeDural2016]
KMT2D	Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@liLossCREBBPKMT2D2024], CE[@rushtonGeneticEvolutionaryPatterns2020], aSHM	Morin et al	[@beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020; @grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012c]
MAP2K1	Tier 1 GE[@louissaintPediatrictypeNodalFollicular2016a], aSHM	Louissaint et al	[@shinBRAFV600EMAP2K12015]
MEF2B	Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@yingMEF2BMutationsLead], aSHM	Morin et al	[@beaLandscapeSomaticMutations2013]
MYC	Tier 1 GE, FE[@giallongoIdentificationCmycOncogene1983], CE[@christieCMYCTranslocation142008], aSHM		[@dunsCharacterizationDLBCLPMBL2021b; @jalladesExomeSequencingIdentifies2017; @johnstonCmycHypermutationBurkitt1992; @pasqualucciHypermutationMultipleProtooncogenes2001a]
PIM1	Tier 1 GE[@drevalGeneticSubdivisionsFollicular2023], CE[@guoSGK1MutationStatus2022b], aSHM	Dreval et al	[@burkhardtClinicalRelevanceMolecular2022b; @dunsCharacterizationDLBCLPMBL2021b; @pasqualucciHypermutationMultipleProtooncogenes2001a]
POU2AF1	Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], aSHM	Krysiak et al	[@chapuyMolecularSubtypesDiffuse2018b]
POU2F2	Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], FE[@hodsonRegulationNormalBcell2016a], aSHM	Krysiak et al	[@lohrDiscoveryPrioritizationSomatic2012a]
RRAGC	Tier 1 GE[@okosunRecurrentMTORC1activatingRRAGC2016a], FE[@ortega-molinaOncogenicRagGTPase2019b], aSHM	Okosun et al
SGK1	Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@hartmannHighlyRecurrentMutations2016b], CE[@guoSGK1MutationStatus2022b], aSHM	Morin et al	[@dunsCharacterizationDLBCLPMBL2021b]
SMARCA4	Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], FE[@dengSMARCA4HaploinsufficientCell2024], aSHM	Krysiak et al	[@nadeuGenomicEpigenomicInsights2020b; @reddyGeneticFunctionalDrivers2017; @richterRecurrentMutationID32012a]
SOCS1	Tier 1 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@melznerBiallelicMutationSOCS12005a], aSHM	Dreval et al	[@morinFrequentMutationHistonemodifying2011; @wenigerMutationsTumorSuppressor2006a]
STAT6	Tier 1 GE[@yildizActivatingSTAT6Mutations2015c], FE[@yildizActivatingSTAT6Mutations2015c], aSHM	Yildiz et al	[@ritzRecurrentMutationsSTAT62009a]
TBL1XR1	Tier 1 GE, FE[@venturuttiTBL1XR1MutationsDrive2020b], aSHM		[@lohrDiscoveryPrioritizationSomatic2012a; @rossiCodingGenomeSplenic2012c]
TMSB4X	Tier 1 GE, aSHM		[@zhangGeneticHeterogeneityDiffuse2013]
TNFAIP3	Tier 1 GE, FE[@compagnoMutationsMultipleGenes2009a], aSHM		[@compagnoMutationsMultipleGenes2009a; @rossiAlterationBIRC3Multiple2011a; @schmitzTNFAIP3A20Tumor2009a]
TNFRSF14	Tier 1 GE[@cheungAcquiredTNFRSF14Mutations2010a], CE[@guoSGK1MutationStatus2022b], aSHM	Cheung et al	[@morinFrequentMutationHistonemodifying2011; @spinaGeneticsNodalMarginal2016b]
TP53	Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@rowhTp53DeletionLineage2011], aSHM	Morin et al	[@beaLandscapeSomaticMutations2013; @lohrDiscoveryPrioritizationSomatic2012a; @rossiCodingGenomeSplenic2012c; @tiacciPervasiveMutationsJAKSTAT2018b; @wildaInactivationARFMDM2p53Pathway2004]
VMA21	Tier 1 GE[@hubschmannMutationalMechanismsShaping2021b]	Hubschmann et al

Tier 2, low-confidence FL genes

59 total

Gene	Summary	First FL study	Other entities	QC result
ABL2	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b]	Russler-germain et al
ACTG1	Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b], aSHM	Hubschmann et al	[@deschGenotypingCirculatingTumor2020; @spinaGeneticsNodalMarginal2016b]
ATP6V1A	Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b]	Hubschmann et al
BIRC6	Tier 2 GE, aSHM		[@reddyGeneticFunctionalDrivers2017; @sarkozyMutationalLandscapeGray2021a]
BTG1	Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@mlynarczykBTG1MutationYields2023b], aSHM	Dreval et al	[@burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011; @sarkozyMutationalLandscapeGray2021a]
BTG2	Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], CE[@guoMutationBTG2Gene2022b], aSHM	Dreval et al	[@loveGeneticLandscapeMutations2012; @morinFrequentMutationHistonemodifying2011]
CD70	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b], aSHM	Russler-germain et al	[@morinFrequentMutationHistonemodifying2011]
CD79B	Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@davisChronicActiveBcellreceptor2010], aSHM	Dreval et al	[@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]
CDC42BPB	Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b]	Hubschmann et al	[@spinaGeneticsNodalMarginal2016b]
CILP	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b]	Russler-germain et al
CPNE8	Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b]	Hubschmann et al
CXCR4	Tier 2 GE[@krysiakRecurrentSomaticMutations2017b], aSHM	Krysiak et al	[@khodabakhshiRecurrentTargetsAberrant2012; @paneaWholeGenomeLandscape2019]
CYP2A6	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b]	Russler-germain et al
DDX3X	Tier 2 GE, FE[@gongSequentialInverseDysregulation2021], CE[@kizhakeyilDDX3XLossAdverse2021], aSHM		[@mottokIntegrativeGenomicAnalysis2019b; @reddyGeneticFunctionalDrivers2017; @schmitzBurkittLymphomaPathogenesis2012]
DHX15	Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b]	Hubschmann et al
DTX1	Tier 2 GE, FE[@demirandaExomeSequencingReveals2014], CE[@merirantaDeltex1MutationsPredict2017b], aSHM		[@gomezUltraDeepSequencingReveals2023; @loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @zhangGeneticHeterogeneityDiffuse2013]
DUSP2	Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], aSHM	Dreval et al	[@dunsCharacterizationDLBCLPMBL2021b; @lohrDiscoveryPrioritizationSomatic2012a]
EGR1	Tier 2 GE[@krysiakRecurrentSomaticMutations2017b]	Krysiak et al	[@reichelFlowSortingExome2015a; @rossiCodingGenomeSplenic2012c]
FZR1	Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b]	Hubschmann et al
GBP7	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b]	Russler-germain et al
GRM6	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b]	Russler-germain et al
HIST1H2BD	Tier 2 GE[@krysiakRecurrentSomaticMutations2017b]	Krysiak et al
HIST1H2BM	Tier 2 GE[@krysiakRecurrentSomaticMutations2017b]	Krysiak et al
HIST1H3B	Tier 2 GE, aSHM		[@lohrDiscoveryPrioritizationSomatic2012a; @reichelFlowSortingExome2015a]
HIST1H3G	Tier 2 GE[@krysiakRecurrentSomaticMutations2017b]	Krysiak et al
HIST1H3I	Tier 2 GE[@krysiakRecurrentSomaticMutations2017b]	Krysiak et al	[@paneaWholeGenomeLandscape2019]
HLA-B	Tier 2 GE, aSHM		[@lohrDiscoveryPrioritizationSomatic2012a; @wienandGenomicAnalysesFlowsorted2019b]
IGLL5	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b], aSHM	Russler-germain et al	[@chapuyMolecularSubtypesDiffuse2018b; @deschGenotypingCirculatingTumor2020; @paneaWholeGenomeLandscape2019]
ITPKB	Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], aSHM	Dreval et al	[@reichelFlowSortingExome2015a; @schmitzGeneticsPathogenesisDiffuse2018a]
JUP	Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b]	Hubschmann et al
KIR3DL1	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b]	Russler-germain et al
KLF2	Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], aSHM	Dreval et al	[@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017; @pasqualucciAnalysisCodingGenome2011]
LAPTM5	Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b], aSHM	Hubschmann et al
LTB	Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], aSHM	Dreval et al	[@chapuyMolecularSubtypesDiffuse2018b; @deschGenotypingCirculatingTumor2020]
MAGEC1	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b]	Russler-germain et al
MAP7D1	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b]	Russler-germain et al
MEF2C	Tier 2 GE, FE[@jingjingNovelMEF2CMutation2020], aSHM		[@arthurGenomewideDiscoverySomatic2018]
MGEA5	Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b]	Hubschmann et al
MKI67	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b]	Russler-germain et al	[@schmitzBurkittLymphomaPathogenesis2012]
MYCBP2	Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b]	Hubschmann et al
MYD88	Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@ngoOncogenicallyActiveMYD882011a], CE[@guoSGK1MutationStatus2022b], aSHM	Dreval et al	[@ngoOncogenicallyActiveMYD882011a; @yanBCRTLRSignaling2012a]
NFKBIA	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b], aSHM	Russler-germain et al	[@thomasMutationalAnalysisIkappaBalpha2004; @wienandGenomicAnalysesFlowsorted2019b]
OR8H2	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b]	Russler-germain et al
P2RY8	Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@muppidiLossSignalingGa132014b], aSHM	Dreval et al	[@lohrDiscoveryPrioritizationSomatic2012a; @muppidiLossSignalingGa132014b]
PDS5B	Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b], aSHM	Hubschmann et al	[@morinMutationalStructuralAnalysis2013]
PPP4C	Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b]	Hubschmann et al
PRKDC	Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b], aSHM	Hubschmann et al	[@schmitzGeneticsPathogenesisDiffuse2018a]
PTPRD	Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], aSHM	Dreval et al	[@spinaGeneticsNodalMarginal2016b]
PZP	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b]	Russler-germain et al
RBM6	Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b]	Hubschmann et al
S1PR2	Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@floriHematopoieticOncoproteinFOXP12016], aSHM	Dreval et al	[@morinFrequentMutationHistonemodifying2011; @muppidiLossSignalingGa132014b]
SHROOM3	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b]	Russler-germain et al
SRRM2	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b], aSHM	Russler-germain et al	[@morinMutationalStructuralAnalysis2013]
STAB2	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b]	Russler-germain et al
TMEM30A	Tier 2 GE[@morinFrequentMutationHistonemodifying2011], FE[@ennishiTMEM30ALossoffunctionMutations2020b], CE[@ennishiTMEM30ALossoffunctionMutations2020b], aSHM	Morin et al
TPP1	Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b]	Hubschmann et al
XIRP2	Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b]	Russler-germain et al
ZC3H12A	Tier 2 GE, aSHM		[@chapuyMolecularSubtypesDiffuse2018b]
ZNF608	Tier 2 GE[@krysiakRecurrentSomaticMutations2017b], aSHM	Krysiak et al	[@morinMutationalStructuralAnalysis2013]

Tier 3, retired FL genes

0 total

Gene	Summary	First FL study	Other entities	QC result

References