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Ryan Morin edited this page Dec 16, 2024 · 24 revisions

bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

[[TOC]]

Overview

KRAS mutations are rare but occur in some cases of DLBCL.1 These often affect the most common KRAS hotspot sites that are mutated in other solid cancers (G12 and G13).

Relevance tier by entity

Entity Tier Description
DLBCL 1 high-confidence DLBCL gene[@lohrDiscoveryPrioritizationSomatic2012]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

include:DLBCL_KRAS.md

Mutation pattern and selective pressure estimates

include:dnds_KRAS.md

KRAS Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chr12 25398285 C>A G12C
chr12 25398284 C>T G12D
chr12 25398284 C>A G12V
chr12 25398282 C>A G13C
chr12 25398281 C>T G13D

include:browser_KRAS.md

Expression

include:mermaid_KRAS.md

References

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