MZL_genes
| Gene | Summary | First MZL study | Other entities | QC result |
|---|---|---|---|---|
| ACTB | Tier 1 GE, aSHM | [@drevalGeneticSubdivisionsFollicular2023; @lohrDiscoveryPrioritizationSomatic2012; @wienandGenomicAnalysesFlowsorted2019] | ||
| ARID1A | Tier 1 GE[@rossiCodingGenomeSplenic2012], FE[@barisicARID1AOrchestratesSWI2024] | Rossi et al | [@krysiakRecurrentSomaticMutations2017; @loveGeneticLandscapeMutations2012; @wienandGenomicAnalysesFlowsorted2019; @zhangGeneticHeterogeneityDiffuse2013] | |
| ATM | Tier 1 GE[@braggioGenomicAnalysisMarginal2012], FE[@camachoATMGeneInactivation2002] | Braggio et al | [@beaLandscapeSomaticMutations2013; @reddyGeneticFunctionalDrivers2017] | |
| BCL10 | Tier 1 GE[@spinaGeneticsNodalMarginal2016], FE[@xiaBCL10MutationsDefine2022] | Spina et al | [@morinFrequentMutationHistonemodifying2011; @russler-germainMutationsAssociatedProgression2023] | |
| BCL7A | Tier 1 GE, FE[@balinas-gaviraFrequentMutationsAminoterminal2020], aSHM | [@grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017; @morinFrequentMutationHistonemodifying2011; @reichelFlowSortingExome2015] | ||
| BIRC3 | Tier 1 GE[@rossiAlterationBIRC3Multiple2011], aSHM | Rossi et al | [@arthurGenomewideDiscoverySomatic2018; @beaLandscapeSomaticMutations2013; @dunsCharacterizationDLBCLPMBL2021] | |
| BRAF | Tier 1 GE, FE[@wanMechanismActivationRAFERK2004] | [@loveGeneticLandscapeMutations2012; @tiacciBRAFMutationsHairycell2011] | ||
| BTG1 | Tier 1 GE, FE[@almasmoumFrequentLossBTG12021], aSHM | [@burkhardtClinicalRelevanceMolecular2022; @drevalGeneticSubdivisionsFollicular2023; @morinFrequentMutationHistonemodifying2011; @sarkozyMutationalLandscapeGray2021] | ||
| CARD11 | Tier 1 GE[@yanBCRTLRSignaling2012], FE[@lenzOncogenicCARD11Mutations2008] | Yan et al | [@lenzOncogenicCARD11Mutations2008; @morinFrequentMutationHistonemodifying2011; @wuGeneticHeterogeneityPrimary2016] | |
| CCND3 | Tier 1 GE[@jalladesExomeSequencingIdentifies2017], FE[@schmitzBurkittLymphomaPathogenesis2012] | Jallades et al | [@deschGenotypingCirculatingTumor2020; @morinFrequentMutationHistonemodifying2011; @richterRecurrentMutationID32012] | |
| CXCR4 | Tier 1 GE, FE[@zmajkovicovaGenotypephenotypeCorrelationsWHIM2022], aSHM | [@khodabakhshiRecurrentTargetsAberrant2012; @krysiakRecurrentSomaticMutations2017; @paneaWholeGenomeLandscape2019] | ||
| DTX1 | Tier 1 GE[@rossiCodingGenomeSplenic2012], aSHM | Rossi et al | [@gomezUltraDeepSequencingReveals2023; @loveGeneticLandscapeMutations2012; @zhangGeneticHeterogeneityDiffuse2013] | |
| EP300 | Tier 1 GE[@rossiCodingGenomeSplenic2012], FE[@pasqualucciInactivatingMutationsAcetyltransferase2011] | Rossi et al | [@pasqualucciInactivatingMutationsAcetyltransferase2011] | |
| EZH2 | Tier 1 GE, FE[@sneeringerCoordinatedActivitiesWildtype2010] | [@loveGeneticLandscapeMutations2012; @morinSomaticMutationsAltering2010; @mottokIntegrativeGenomicAnalysis2019] | ||
| FAS | Tier 1 GE[@spinaGeneticsNodalMarginal2016], FE[@wangFasFADDDeathDomain2010] | Spina et al | [@morinFrequentMutationHistonemodifying2011; @schollMutationsRegionFAS2007] | |
| FAT1 | Tier 1 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
| FOXO1 | Tier 1 GE, FE[@trinhAnalysisFOXO1Mutations] | [@dunsCharacterizationDLBCLPMBL2021; @morinFrequentMutationHistonemodifying2011; @schmitzBurkittLymphomaPathogenesis2012] | ||
| H1-4 | Tier 1 GE | |||
| H1-5 | Tier 1 GE | |||
| ID3 | Tier 1 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@richterRecurrentMutationID32012; @schmitzGeneticsPathogenesisDiffuse2018] | |
| KLF2 | Tier 1 GE[@jalladesExomeSequencingIdentifies2017], aSHM | Jallades et al | [@deschGenotypingCirculatingTumor2020; @drevalGeneticSubdivisionsFollicular2023; @pasqualucciAnalysisCodingGenome2011] | |
| KLHL6 | Tier 1 GE[@ganapathiGeneticLandscapeDural2016], FE[@choiLossKLHL6Promotes2018], aSHM | Ganapathi et al | [@morinFrequentMutationHistonemodifying2011] | |
| KMT2D | Tier 1 GE[@rossiCodingGenomeSplenic2012], FE[@zhangDisruptionKMT2DPerturbs2015] | Rossi et al | [@beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020; @grandeGenomewideDiscoverySomatic2019; @morinFrequentMutationHistonemodifying2011] | |
| MAP3K14 | Tier 1 GE[@rossiAlterationBIRC3Multiple2011] | Rossi et al | [@ottoGeneticLesionsTRAF32012] | |
| MPEG1 | Tier 1 GE | [@morinMutationalStructuralAnalysis2013] | ||
| MYD88 | Tier 1 GE[@yanBCRTLRSignaling2012], FE[@ngoOncogenicallyActiveMYD882011] | Yan et al | [@drevalGeneticSubdivisionsFollicular2023; @ngoOncogenicallyActiveMYD882011] | |
| NCOR2 | Tier 1 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@sarkozyMutationalLandscapeGray2021; @schmitzBurkittLymphomaPathogenesis2012] | |
| NOL9 | Tier 1 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@schmitzGeneticsPathogenesisDiffuse2018] | |
| NOTCH1 | Tier 1 GE[@rossiCodingGenomeSplenic2012], FE[@ryanCellRegulomeLinks2017] | Rossi et al | [@beaLandscapeSomaticMutations2013; @loveGeneticLandscapeMutations2012; @pasqualucciAnalysisCodingGenome2011] | |
| NOTCH2 | Tier 1 GE[@rossiCodingGenomeSplenic2012], FE[@leeGainoffunctionMutationsCopy2009] | Rossi et al | [@beaLandscapeSomaticMutations2013; @zhangGeneticHeterogeneityDiffuse2013] | |
| PCLO | Tier 1 GE | [@lohrDiscoveryPrioritizationSomatic2012] | ||
| POU2AF1 | Tier 1 GE, FE[@gonzalez-rinconUnravelingTransformationFollicular2019], aSHM | [@chapuyMolecularSubtypesDiffuse2018; @krysiakRecurrentSomaticMutations2017] | ||
| PTPRD | Tier 1 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@drevalGeneticSubdivisionsFollicular2023] | |
| SIN3A | Tier 1 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | [@chapuyMolecularSubtypesDiffuse2018; @grandeGenomewideDiscoverySomatic2019] | |
| SOCS1 | Tier 1 GE, FE[@melznerBiallelicMutationSOCS12005], aSHM | [@drevalGeneticSubdivisionsFollicular2023; @morinFrequentMutationHistonemodifying2011; @wenigerMutationsTumorSuppressor2006] | ||
| SPEN | Tier 1 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | [@albuquerqueEnhancingKnowledgeDiscovery2017; @sarkozyMutationalLandscapeGray2021] | |
| STAT6 | Tier 1 GE, FE[@mentzPARP14NovelTarget2022] | [@ritzRecurrentMutationsSTAT62009; @yildizActivatingSTAT6Mutations2015] | ||
| TBL1XR1 | Tier 1 GE[@rossiCodingGenomeSplenic2012], FE[@venturuttiTBL1XR1MutationsDrive2020] | Rossi et al | [@drevalGeneticSubdivisionsFollicular2023; @lohrDiscoveryPrioritizationSomatic2012] | |
| TNFAIP3 | Tier 1 GE[@rossiAlterationBIRC3Multiple2011], FE[@compagnoMutationsMultipleGenes2009] | Rossi et al | [@compagnoMutationsMultipleGenes2009; @drevalGeneticSubdivisionsFollicular2023; @schmitzTNFAIP3A20Tumor2009] | |
| TNFRSF14 | Tier 1 GE[@spinaGeneticsNodalMarginal2016], FE[@] | Spina et al | [@cheungAcquiredTNFRSF14Mutations2010; @morinFrequentMutationHistonemodifying2011] | |
| TP53 | Tier 1 GE[@rossiCodingGenomeSplenic2012], FE[@katoUnderstandingFunctionstructureFunctionmutation2003] | Rossi et al | [@beaLandscapeSomaticMutations2013; @morinFrequentMutationHistonemodifying2011; @tiacciPervasiveMutationsJAKSTAT2018; @wildaInactivationARFMDM2p53Pathway2004] | |
| TRAF3 | Tier 1 GE[@rossiAlterationBIRC3Multiple2011] | Rossi et al | [@ottoGeneticLesionsTRAF32012; @pasqualucciAnalysisCodingGenome2011] |
| Gene | Summary | First MZL study | Other entities | QC result |
|---|---|---|---|---|
| ABCA13 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@sarkozyMutationalLandscapeGray2021] | |
| ACTG1 | Tier 2 GE[@spinaGeneticsNodalMarginal2016], aSHM | Spina et al | [@deschGenotypingCirculatingTumor2020; @fanComprehensiveCharacterizationDriver2020; @hubschmannMutationalMechanismsShaping2021] | |
| ADD2 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
| AMN | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
| AMOTL1 | Tier 2 GE[@parryWholeExomeSequencing2013] | Parry et al | ||
| AOC2 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
| ARHGAP20 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| ARHGEF15 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| ARHGEF17 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| BCOR | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | [@nadeuGenomicEpigenomicInsights2020b] | |
| C6orf103 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
| CBFA2T3 | Tier 2 GE[@parryWholeExomeSequencing2013] | Parry et al | ||
| CD79A | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | [@burkhardtClinicalRelevanceMolecular2022] | |
| CD9B | Tier 2 GE[@vandenbrandRecurrentMutationsGenes2017] | Vandenbrand et al | ||
| CDC42BPB | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@hubschmannMutationalMechanismsShaping2021] | |
| CDKN2A | Tier 2 GE[@spinaGeneticsNodalMarginal2016], FE[@kannengiesserFunctionalStructuralGenetic2009] | Spina et al | [@grandeGenomewideDiscoverySomatic2019; @morinMutationalStructuralAnalysis2013] | |
| CLGN | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
| CNBP | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
| CNKSR2 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
| CREBBP | Tier 2 GE[@parryWholeExomeSequencing2013], FE[@pasqualucciInactivatingMutationsAcetyltransferase2011] | Parry et al | [@dunsCharacterizationDLBCLPMBL2021; @loveGeneticLandscapeMutations2012; @pasqualucciInactivatingMutationsAcetyltransferase2011] | |
| DNAH5 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | [@morinMutationalStructuralAnalysis2013] | |
| DNAH7 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| DNAI1 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| DOCK6 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| DSP | Tier 2 GE | [@zhangGeneticHeterogeneityDiffuse2013] | ||
| DTNB | Tier 2 GE | |||
| DTX3L | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| EGR1 | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | [@krysiakRecurrentSomaticMutations2017; @reichelFlowSortingExome2015] | |
| EGR2 | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | ||
| EZH1 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| FAT4 | Tier 2 GE[@parryWholeExomeSequencing2013] | Parry et al | [@morinMutationalStructuralAnalysis2013; @zhangGenomicLandscapeMantle2014] | |
| FBXO11 | Tier 2 GE[@parryWholeExomeSequencing2013], FE[@duanFBXO11TargetsBCL62011] | Parry et al | [@arthurGenomewideDiscoverySomatic2018; @richterRecurrentMutationID32012] | |
| GPR98 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
| GPS2 | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | ||
| HIST1H1D | Tier 2 GE[@jalladesExomeSequencingIdentifies2017], aSHM | Jallades et al | [@krysiakRecurrentSomaticMutations2017; @morinMutationalStructuralAnalysis2013] | |
| HIST1H2AD | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| HIST1H2AG | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | [@krysiakRecurrentSomaticMutations2017; @morinMutationalStructuralAnalysis2013; @paneaWholeGenomeLandscape2019] | |
| HIST1H2BK | Tier 2 GE[@rossiCodingGenomeSplenic2012], aSHM | Rossi et al | [@paneaWholeGenomeLandscape2019; @zhangGeneticHeterogeneityDiffuse2013] | |
| HIST4H4 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| HRAS | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | [@reddyGeneticFunctionalDrivers2017] | |
| IKBKB | Tier 2 GE[@rossiAlterationBIRC3Multiple2011] | Rossi et al | [@reddyGeneticFunctionalDrivers2017; @wienandGenomicAnalysesFlowsorted2019] | |
| KAT6A | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| KDM6A | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| KIF26A | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| LRP1B | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@zhangGeneticHeterogeneityDiffuse2013] | |
| MCRS1 | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | ||
| MGA | Tier 2 GE[@jalladesExomeSequencingIdentifies2017], FE[@depaoliMGASuppressorMYC2013] | Jallades et al | [@reddyGeneticFunctionalDrivers2017] | |
| MSL2 | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | ||
| MYC | Tier 2 GE[@jalladesExomeSequencingIdentifies2017], FE[@freieGermlinePointMutation2024], aSHM | Jallades et al | [@dunsCharacterizationDLBCLPMBL2021; @johnstonCmycHypermutationBurkitt1992; @pasqualucciHypermutationMultipleProtooncogenes2001] | |
| MYLK | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| NCOA6 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| NRAS | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| PACRG | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
| PARK2 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
| PLA2G4D | Tier 2 GE[@parryWholeExomeSequencing2013] | Parry et al | ||
| PLXNB3 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@zhangGenomicLandscapeMantle2014] | |
| RAF1 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | [@fanComprehensiveCharacterizationDriver2020] | |
| RAPGEF2 | Tier 2 GE | [@zhangGeneticHeterogeneityDiffuse2013] | ||
| RCOR1 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
| RFTN1 | Tier 2 GE, aSHM | [@arthurGenomewideDiscoverySomatic2018; @dunsCharacterizationDLBCLPMBL2021] | ||
| ROCK1 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| RPL1L | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
| SAMD5 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
| SCG3 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
| STXBP5 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
| SWAP70 | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | ||
| TAF1 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@morinMutationalStructuralAnalysis2013] | |
| TBK1 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
| TCTN2 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
| TNIP2 | Tier 2 GE[@vandenbrandRecurrentMutationsGenes2017] | Vandenbrand et al | ||
| TRRAP | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | [@zhangGeneticHeterogeneityDiffuse2013] | |
| USH2A | Tier 2 GE[@parryWholeExomeSequencing2013] | Parry et al | ||
| WAC | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | [@reddyGeneticFunctionalDrivers2017] | |
| WNK1 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | [@hubschmannMutationalMechanismsShaping2021; @thomasGeneticSubgroupsInform2023] |
| Gene | Summary | First MZL study | Other entities | QC result |
|---|
Disclaimer
The content in these pages has been populated, in part, by an automated process. Although we have scrutinized every page to ensure accuracy, errors will inevitably exist. If you find an error please report it as an issue and we will address it.
In particular, let us know if you feel that an important citation is missing or if a paper has been cited incorrectly.
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms.