MZL_genes

---

title: 'MZL genes' bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

Origins of MZL genes

Tier 1 MZL genes

42 total

Gene	Tier	First MZL evidence	Other entities
ACTB	1		[@wienandGenomicAnalysesFlowsorted2019b; @lohrDiscoveryPrioritizationSomatic2012a]
ARID1A	1	[@rossiCodingGenomeSplenic2012c]	[@krysiakRecurrentSomaticMutations2017b; @zhangGeneticHeterogeneityDiffuse2013; @wienandGenomicAnalysesFlowsorted2019b; @loveGeneticLandscapeMutations2012]
ATM	1	[@braggioGenomicAnalysisMarginal2012]	[@reddyGeneticFunctionalDrivers2017; @beaLandscapeSomaticMutations2013]
BCL10	1	[@spinaGeneticsNodalMarginal2016b]	[@russler-germainMutationsAssociatedProgression2023b; @morinFrequentMutationHistonemodifying2011]
BCL7A	1		[@arthurGenomewideDiscoverySomatic2018; @grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017b; @reichelFlowSortingExome2015a]
BIRC3	1	[@rossiAlterationBIRC3Multiple2011a]	[@beaLandscapeSomaticMutations2013; @arthurGenomewideDiscoverySomatic2018; @dunsCharacterizationDLBCLPMBL2021b]
BRAF	1		[@tiacciBRAFMutationsHairycell2011a; @loveGeneticLandscapeMutations2012]
BTG1	1		[@morinFrequentMutationHistonemodifying2011; @burkhardtClinicalRelevanceMolecular2022b; @sarkozyMutationalLandscapeGray2021a]
CARD11	1	[@yanBCRTLRSignaling2012a]	[@paneaWholeGenomeLandscape2019; @wuGeneticHeterogeneityPrimary2016; @morinFrequentMutationHistonemodifying2011; @lenzOncogenicCARD11Mutations2008]
CCND3	1	[@jalladesExomeSequencingIdentifies2017]	[@morinFrequentMutationHistonemodifying2011; @deschGenotypingCirculatingTumor2020; @richterRecurrentMutationID32012a]
CXCR4	1		[@paneaWholeGenomeLandscape2019; @krysiakRecurrentSomaticMutations2017b; @khodabakhshiRecurrentTargetsAberrant2012]
DTX1	1	[@rossiCodingGenomeSplenic2012c]	[@gomezUltraDeepSequencingReveals2023; @schmitzGeneticsPathogenesisDiffuse2018a; @paneaWholeGenomeLandscape2019]
EP300	1	[@rossiCodingGenomeSplenic2012c]	[@paneaWholeGenomeLandscape2019; @pasqualucciInactivatingMutationsAcetyltransferase2011a]
EZH2	1		[@mottokIntegrativeGenomicAnalysis2019b; @morinSomaticMutationsAltering2010a; @loveGeneticLandscapeMutations2012]
FAS	1	[@spinaGeneticsNodalMarginal2016b]	[@schollMutationsRegionFAS2007]
FAT1	1	[@spinaGeneticsNodalMarginal2016b]
FOXO1	1		[@morinFrequentMutationHistonemodifying2011; @dunsCharacterizationDLBCLPMBL2021b; @schmitzBurkittLymphomaPathogenesis2012]
H1-4	1
H1-5	1
ID3	1	[@spinaGeneticsNodalMarginal2016b]	[@schmitzBurkittLymphomaPathogenesis2012; @richterRecurrentMutationID32012a]
KLF2	1	[@jalladesExomeSequencingIdentifies2017]	[@deschGenotypingCirculatingTumor2020; @pasqualucciAnalysisCodingGenome2011]
KLHL6	1	[@ganapathiGeneticLandscapeDural2016]	[@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]
KMT2D	1	[@rossiCodingGenomeSplenic2012c]	[@morinFrequentMutationHistonemodifying2011; @grandeGenomewideDiscoverySomatic2019; @deschGenotypingCirculatingTumor2020; @beaLandscapeSomaticMutations2013]
MAP3K14	1	[@rossiAlterationBIRC3Multiple2011a]	[@ottoGeneticLesionsTRAF32012a]
MPEG1	1		[@morinMutationalStructuralAnalysis2013]
MYD88	1	[@yanBCRTLRSignaling2012a]	[@ngoOncogenicallyActiveMYD882011a]
NCOR2	1	[@spinaGeneticsNodalMarginal2016b]	[@schmitzBurkittLymphomaPathogenesis2012; @sarkozyMutationalLandscapeGray2021a]
NOL9	1	[@spinaGeneticsNodalMarginal2016b]	[@schmitzGeneticsPathogenesisDiffuse2018a]
NOTCH1	1	[@rossiCodingGenomeSplenic2012c]	[@pasqualucciAnalysisCodingGenome2011; @beaLandscapeSomaticMutations2013; @loveGeneticLandscapeMutations2012]
NOTCH2	1	[@rossiCodingGenomeSplenic2012c]	[@paneaWholeGenomeLandscape2019; @beaLandscapeSomaticMutations2013; @troenNOTCH2MutationsMarginal2008]
PCLO	1		[@lohrDiscoveryPrioritizationSomatic2012a]
POU2AF1	1		[@krysiakRecurrentSomaticMutations2017b]
PTPRD	1	[@spinaGeneticsNodalMarginal2016b]
SIN3A	1	[@rossiCodingGenomeSplenic2012c]	[@grandeGenomewideDiscoverySomatic2019]
SOCS1	1		[@morinFrequentMutationHistonemodifying2011; @wenigerMutationsTumorSuppressor2006a]
SPEN	1	[@rossiCodingGenomeSplenic2012c]	[@sarkozyMutationalLandscapeGray2021a]
STAT6	1		[@yildizActivatingSTAT6Mutations2015c; @ritzRecurrentMutationsSTAT62009a]
TBL1XR1	1	[@rossiCodingGenomeSplenic2012c]	[@mareschalWholeExomeSequencing2016]
TNFAIP3	1	[@rossiAlterationBIRC3Multiple2011a]	[@compagnoMutationsMultipleGenes2009a; @schmitzTNFAIP3A20Tumor2009a]
TNFRSF14	1	[@spinaGeneticsNodalMarginal2016b]	[@cheungAcquiredTNFRSF14Mutations2010a]
TP53	1	[@rossiCodingGenomeSplenic2012c]	[@morinFrequentMutationHistonemodifying2011; @wildaInactivationARFMDM2p53Pathway2004; @beaLandscapeSomaticMutations2013; @tiacciPervasiveMutationsJAKSTAT2018b]
TRAF3	1	[@rossiAlterationBIRC3Multiple2011a]	[@pasqualucciAnalysisCodingGenome2011; @ottoGeneticLesionsTRAF32012a]

Tier 2 MZL genes

74 total

Gene	Tier	First MZL evidence	Other entities
ABCA13	2	[@spinaGeneticsNodalMarginal2016b]	[@sarkozyMutationalLandscapeGray2021a]
ACTG1	2	[@spinaGeneticsNodalMarginal2016b]	[@hubschmannMutationalMechanismsShaping2021b; @deschGenotypingCirculatingTumor2020]
ADD2	2	[@spinaGeneticsNodalMarginal2016b]
AMN	2	[@spinaGeneticsNodalMarginal2016b]
AMOTL1	2	[@parryWholeExomeSequencing2013]
AOC2	2	[@spinaGeneticsNodalMarginal2016b]
ARHGAP20	2	[@jalladesExomeSequencingIdentifies2017]
ARHGEF15	2	[@jalladesExomeSequencingIdentifies2017]
ARHGEF17	2	[@jalladesExomeSequencingIdentifies2017]
BCOR	2	[@jalladesExomeSequencingIdentifies2017]	[@nadeuGenomicEpigenomicInsights2020b]
C6orf103	2	[@spinaGeneticsNodalMarginal2016b]
CBFA2T3	2	[@parryWholeExomeSequencing2013]
CD79A	2	[@rossiCodingGenomeSplenic2012c]	[@burkhardtClinicalRelevanceMolecular2022b]
CD9B	2	[@vandenbrandRecurrentMutationsGenes2017]
CDC42BPB	2	[@spinaGeneticsNodalMarginal2016b]
CDKN2A	2	[@spinaGeneticsNodalMarginal2016b]	[@morinMutationalStructuralAnalysis2013; @grandeGenomewideDiscoverySomatic2019]
CLGN	2	[@spinaGeneticsNodalMarginal2016b]
CNKSR2	2	[@spinaGeneticsNodalMarginal2016b]
CREBBP	2	[@parryWholeExomeSequencing2013]	[@loveGeneticLandscapeMutations2012; @pasqualucciInactivatingMutationsAcetyltransferase2011a; @dunsCharacterizationDLBCLPMBL2021b]
DNAH5	2	[@jalladesExomeSequencingIdentifies2017]	[@morinMutationalStructuralAnalysis2013]
DNAH7	2	[@jalladesExomeSequencingIdentifies2017]
DNAI1	2	[@jalladesExomeSequencingIdentifies2017]
DOCK6	2	[@jalladesExomeSequencingIdentifies2017]
DSP	2
DTNB	2
DTX3L	2	[@jalladesExomeSequencingIdentifies2017]
EGR1	2	[@rossiCodingGenomeSplenic2012c]	[@krysiakRecurrentSomaticMutations2017b; @reichelFlowSortingExome2015a]
EGR2	2	[@rossiCodingGenomeSplenic2012c]
EZH1	2	[@jalladesExomeSequencingIdentifies2017]
FAT4	2	[@parryWholeExomeSequencing2013]	[@morinMutationalStructuralAnalysis2013; @zhangGenomicLandscapeMantle2014]
FBXO11	2	[@parryWholeExomeSequencing2013]	[@richterRecurrentMutationID32012a; @hubschmannMutationalMechanismsShaping2021b]
GPR98	2	[@spinaGeneticsNodalMarginal2016b]
GPS2	2	[@rossiCodingGenomeSplenic2012c]
HIST1H1D	2	[@jalladesExomeSequencingIdentifies2017]	[@krysiakRecurrentSomaticMutations2017b; @morinMutationalStructuralAnalysis2013]
HIST1H2AD	2	[@jalladesExomeSequencingIdentifies2017]
HIST1H2AG	2	[@rossiCodingGenomeSplenic2012c]	[@morinMutationalStructuralAnalysis2013; @paneaWholeGenomeLandscape2019; @krysiakRecurrentSomaticMutations2017b]
HIST1H2BK	2	[@rossiCodingGenomeSplenic2012c]	[@paneaWholeGenomeLandscape2019]
HIST4H4	2	[@jalladesExomeSequencingIdentifies2017]
HRAS	2	[@jalladesExomeSequencingIdentifies2017]	[@reddyGeneticFunctionalDrivers2017]
IKBKB	2	[@rossiAlterationBIRC3Multiple2011a]	[@wienandGenomicAnalysesFlowsorted2019b; @reddyGeneticFunctionalDrivers2017]
KAT6A	2	[@jalladesExomeSequencingIdentifies2017]
KDM6A	2	[@jalladesExomeSequencingIdentifies2017]
KIF26A	2	[@jalladesExomeSequencingIdentifies2017]
LRP1B	2	[@spinaGeneticsNodalMarginal2016b]
MCRS1	2	[@rossiCodingGenomeSplenic2012c]
MGA	2	[@jalladesExomeSequencingIdentifies2017]	[@zhangGeneticHeterogeneityDiffuse2013]
MSL2	2	[@rossiCodingGenomeSplenic2012c]
MYC	2	[@jalladesExomeSequencingIdentifies2017]	[@johnstonCmycHypermutationBurkitt1992; @dunsCharacterizationDLBCLPMBL2021b; @pasqualucciHypermutationMultipleProtooncogenes2001a]
MYLK	2	[@jalladesExomeSequencingIdentifies2017]
NCOA6	2	[@jalladesExomeSequencingIdentifies2017]
NRAS	2	[@jalladesExomeSequencingIdentifies2017]
PACRG	2	[@spinaGeneticsNodalMarginal2016b]
PARK2	2	[@spinaGeneticsNodalMarginal2016b]
PLA2G4D	2	[@parryWholeExomeSequencing2013]
PLXNB3	2	[@spinaGeneticsNodalMarginal2016b]	[@zhangGenomicLandscapeMantle2014]
RAF1	2	[@jalladesExomeSequencingIdentifies2017]
RAPGEF2	2
RCOR1	2	[@spinaGeneticsNodalMarginal2016b]
RFTN1	2		[@arthurGenomewideDiscoverySomatic2018; @dunsCharacterizationDLBCLPMBL2021b]
ROCK1	2	[@jalladesExomeSequencingIdentifies2017]
RPL1L	2	[@spinaGeneticsNodalMarginal2016b]
SAMD5	2	[@spinaGeneticsNodalMarginal2016b]
SCG3	2	[@spinaGeneticsNodalMarginal2016b]
STXBP5	2	[@spinaGeneticsNodalMarginal2016b]
SWAP70	2	[@rossiCodingGenomeSplenic2012c]
TAF1	2	[@spinaGeneticsNodalMarginal2016b]	[@morinMutationalStructuralAnalysis2013]
TBK1	2	[@jalladesExomeSequencingIdentifies2017]
TCTN2	2	[@spinaGeneticsNodalMarginal2016b]
TNIP2	2	[@vandenbrandRecurrentMutationsGenes2017]
TRRAP	2	[@rossiCodingGenomeSplenic2012c]	[@parryWholeExomeSequencing2013]
USH2A	2	[@parryWholeExomeSequencing2013]
WAC	2	[@rossiCodingGenomeSplenic2012c]	[@reddyGeneticFunctionalDrivers2017]
WNK1	2	[@jalladesExomeSequencingIdentifies2017]	[@hubschmannMutationalMechanismsShaping2021b; @thomasGeneticSubgroupsInform2023]
ZNF9	2	[@spinaGeneticsNodalMarginal2016b]

References