reddyGeneticFunctionalDrivers2017
| Entity | Tier 1 | Tier 2 | Tier 2 Pass | Tier 2 Fail |
|---|---|---|---|---|
| DLBCL | 7 | 53 | 24 | 29 |
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sankey-beta
New to this study, DLBCL Tier 1, 7
New to this study, DLBCL Tier 2, 53
DLBCL Tier 2, Pass QC, 24
DLBCL Tier 2, Fail QC, 29
| Novel gene | DLBCL tier | Average variant quality |
|---|---|---|
| ATM | 1 | ★ ★ ★ ☆ ☆ |
| BIRC6 | 1 | ★ ★ ★ ☆ ☆ |
| HIST1H2BC | 1 | ★ ★ ★ ★ ☆ |
| HNRNPU | 1 | ★ ★ ★ ☆ ☆ |
| SETD1B | 1 | ★ ★ ☆ ☆ ☆ |
| TOX | 1 | ★ ★ ★ ☆ ☆ |
| UBE2A | 1 | ★ ★ ★ ☆ ☆ |
| Novel gene | DLBCL tier | Average variant quality | QC outcome |
|---|---|---|---|
| ARID5B | 2 | ★ ★ ★ ★ ☆ | Pass |
| BTBD3 | 2 | ★ ★ ★ ★ ☆ | Pass |
| SETD5 | 2 | ★ ★ ★ ☆ ☆ | Pass |
| ATR | 2 | ★ ★ ★ ☆ ☆ | Pass |
| BRINP3 | 2 | ★ ★ ★ ☆ ☆ | Pass |
| CASP8 | 2 | ★ ★ ★ ☆ ☆ | Pass |
| TGFBR2 | 2 | ★ ★ ★ ☆ ☆ | Pass |
| TIPARP | 2 | ★ ★ ★ ☆ ☆ | Pass |
| CD22 | 2 | ★ ★ ★ ☆ ☆ | Pass |
| NF1 | 2 | ★ ★ ★ ☆ ☆ | Pass |
| IKBKB | 2 | ★ ★ ★ ☆ ☆ | Pass |
| JUNB | 2 | ★ ★ ★ ☆ ☆ | Pass |
| KCMF1 | 2 | ★ ★ ★ ☆ ☆ | Pass |
| MAGT1 | 2 | ★ ★ ★ ☆ ☆ | Pass |
| MECOM | 2 | ★ ★ ★ ☆ ☆ | Pass |
| PTPN6 | 2 | ★ ★ ★ ☆ ☆ | Pass |
| MET | 2 | ★ ★ ★ ☆ ☆ | Pass |
| ZFX | 2 | ★ ★ ★ ☆ ☆ | Pass |
| YY1 | 2 | ★ ★ ★ ☆ ☆ | Pass |
| FOXP1 | 2 | ★ ★ ★ ☆ ☆ | Pass |
| FUBP1 | 2 | ★ ★ ★ ☆ ☆ | Pass |
| GOLGA5 | 2 | ★ ★ ★ ☆ ☆ | Pass |
| MSH6 | 2 | ★ ★ ★ ☆ ☆ | Pass |
| MCL1 | 2 | ★ ★ ★ ☆ ☆ | Pass |
| ANKRD17 | 2 | ★ ★ ★ ☆ ☆ | Fail |
| CDC73 | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| CHD1 | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| CHD8 | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| CHST2 | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| DCAF6 | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| DDX10 | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| DICER1 | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| HRAS | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| LIN54 | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| MAP4K4 | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| MSH2 | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| GNAS | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| MYB | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| NCOR1 | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| NFKB2 | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| PHF6 | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| PIK3CD | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| PTPRK | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| ZFAT | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| ARID1B | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| RUNX1 | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| CBLB | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| SYK | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| WAC | 2 | ★ ★ ☆ ☆ ☆ | Fail |
| ZBTB7A | 2 | ★ ☆ ☆ ☆ ☆ | Fail |
| RARA | 2 | ★ ☆ ☆ ☆ ☆ | Fail |
| DNMT3A | 2 | ★ ☆ ☆ ☆ ☆ | Fail |
| MARK1 | 2 | ★ ☆ ☆ ☆ ☆ | Fail |
The primary data supporting each of the mutations reported in this study can be viewed in IGV reports along with mutations unique to the GAMBL re-analysis.[@drevalRevisitingReddyDLBCL2023]
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